Jeffrey I Weitz Selected Research

Thrombin

8/2022	State-of-the-Art Mini Review: Dual-Pathway Inhibition to Reduce Arterial and Venous Thromboembolism.
1/2022	Identification of the histidine-rich glycoprotein domains responsible for contact pathway inhibition.
12/2021	The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial.
12/2021	Anticoagulation in patients with kidney failure on dialysis: factor XI as a therapeutic target.
12/2021	Immunothrombosis Biomarkers for Distinguishing Coronavirus Disease 2019 Patients From Noncoronavirus Disease Septic Patients With Pneumonia and for Predicting ICU Mortality.
1/2021	Polyphosphate-induced thrombosis in mice is factor XII dependent and is attenuated by histidine-rich glycoprotein.
1/2020	Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) attenuates fibrin-dependent plasmin generation on thrombin-activated platelets.
12/2019	Biofunctional Lubricant-Infused Vascular Grafts Functionalized with Silanized Bio-Inks Suppress Thrombin Generation and Promote Endothelialization.
12/2019	Lubricant-Infused PET Grafts with Built-In Biofunctional Nanoprobes Attenuate Thrombin Generation and Promote Targeted Binding of Cells.
12/2019	Randomized phase 2 trial comparing JNJ-9375, a thrombin-directed antibody, with apixaban for prevention of venous thrombosis.

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Jeffrey I Weitz Research Topics

Disease

105	Hemorrhage 10/2022 - 07/2003
88	Venous Thromboembolism 10/2022 - 04/2003
79	Thrombosis (Thrombus) 08/2022 - 05/2002
30	Atrial Fibrillation 09/2022 - 04/2004
27	Stroke (Strokes) 09/2022 - 04/2002
25	Neoplasms (Cancer) 01/2022 - 02/2004
21	Venous Thrombosis (Deep-Vein Thrombosis) 01/2021 - 05/2003
17	Thromboembolism 08/2022 - 09/2003
14	Acute Coronary Syndrome 01/2019 - 02/2002
11	Myocardial Infarction 01/2020 - 04/2002
9	COVID-19 12/2021 - 01/2020
9	Sepsis (Septicemia) 12/2021 - 12/2004
9	Pulmonary Embolism 10/2018 - 01/2004
8	Peripheral Arterial Disease 09/2022 - 01/2019
8	Thrombocytopenia (Thrombopenia) 01/2017 - 08/2004
7	Inflammation (Inflammations) 01/2020 - 03/2002
6	Embolism (Embolus) 10/2022 - 04/2012
6	Heart Diseases (Heart Disease) 01/2019 - 01/2003
6	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2018 - 01/2012
4	Cardiovascular Diseases (Cardiovascular Disease) 12/2021 - 09/2002
4	Body Weight (Weight, Body) 10/2018 - 09/2016
4	Neoplasm Metastasis (Metastasis) 11/2008 - 02/2004
3	Critical Illness (Critically Ill) 12/2021 - 01/2021
3	Factor XI Deficiency (Hemophilia C) 04/2021 - 05/2016
3	Vascular System Injuries 01/2020 - 12/2006
3	Ischemic Stroke 01/2019 - 03/2014
3	Unstable Angina 11/2016 - 09/2002
3	Osteoporosis 02/2012 - 07/2006
2	Vascular Diseases (Vascular Disease) 01/2022 - 01/2019
2	Polyps 01/2022 - 01/2021
2	Anemia 12/2021 - 01/2021
2	Pneumonia (Pneumonitis) 12/2021 - 05/2020
2	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 12/2021 - 08/2018
2	Renal Insufficiency (Renal Failure) 12/2021 - 09/2018
2	Wounds and Injuries (Trauma) 10/2020 - 04/2003
2	Embolic Stroke 06/2018 - 09/2016
2	Acquired Immunodeficiency Syndrome (AIDS) 11/2016 - 07/2014

Drug/Important Bio-Agent (IBA)

109	AnticoagulantsIBA 08/2022 - 05/2002
41	Warfarin (Coumadin)FDA LinkGeneric 09/2022 - 04/2003
35	RivaroxabanIBA 10/2022 - 04/2012
32	Vitamin K FDA Link 01/2022 - 04/2004
30	Thrombin FDA Link 08/2022 - 04/2002
29	Heparin (Liquaemin)FDA LinkGeneric 12/2021 - 05/2002
23	edoxabanIBA 09/2022 - 09/2010
21	Dabigatran FDA Link 01/2022 - 01/2009
19	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 08/2022 - 04/2002
19	apixabanIBA 01/2022 - 12/2011
15	Enoxaparin (Lovenox)FDA LinkGeneric 10/2022 - 09/2002
15	FibrinIBA 08/2022 - 03/2002
13	Factor XI (Plasma Thromboplastin Antecedent)IBA 12/2021 - 04/2011
13	fibrin fragment D (D-dimer)IBA 12/2021 - 05/2003
12	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 12/2021 - 09/2002
12	Factor Xa InhibitorsIBA 01/2019 - 03/2005
12	Fondaparinux (Arixtra)FDA Link 03/2017 - 09/2002
10	AntithrombinsIBA 12/2021 - 02/2002
9	Pharmaceutical PreparationsIBA 10/2022 - 01/2003
7	Thromboplastin (Tissue Factor)IBA 09/2010 - 08/2003
6	histidine-rich proteinsIBA 01/2022 - 04/2011
6	Cell-Free Nucleic AcidsIBA 12/2021 - 08/2012
6	Factor XII (Hageman Factor)IBA 01/2021 - 04/2011
5	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 08/2022 - 02/2012
5	Blood Coagulation Factors (Coagulation Factor)IBA 08/2022 - 11/2010
5	Dalteparin (Dalteparin Sodium)FDA Link 12/2021 - 02/2018
5	Fibrinogen (Factor I)FDA Link 12/2021 - 11/2010
5	Fibrinolytic Agents (Antithrombotic Agents)IBA 12/2021 - 08/2003
5	CreatinineIBA 10/2021 - 08/2016
5	Clopidogrel (Plavix)FDA Link 01/2019 - 07/2014
5	Factor Xa (Coagulation Factor Xa)IBA 10/2018 - 03/2005
4	Biomarkers (Surrogate Marker)IBA 12/2021 - 08/2012
4	Protein CIBA 12/2021 - 12/2004
4	Hemoglobins (Hemoglobin)IBA 12/2021 - 01/2018
4	N(4)-oleylcytosine arabinosideIBA 05/2018 - 11/2015
4	idarucizumabIBA 05/2017 - 07/2015
4	Antisense OligonucleotidesIBA 05/2016 - 03/2014
3	PolyphosphatesIBA 01/2022 - 12/2017
3	ZincIBA 01/2021 - 03/2013
3	Proteins (Proteins, Gene)FDA Link 12/2019 - 06/2004
3	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 10/2018 - 08/2016
3	pro-brain natriuretic peptide (1-76)IBA 01/2018 - 09/2016
3	Deoxyribonucleases (DNase)FDA Link 08/2015 - 09/2014
3	ximelagatran (Exanta)IBA 01/2005 - 04/2004
2	Factor XIa (Coagulation Factor XIa)IBA 12/2021 - 01/2020
2	Endothelial Protein C ReceptorIBA 12/2021 - 11/2013
2	abelacimabIBA 12/2021 - 11/2021
2	Histones (Histone)IBA 12/2021 - 09/2014
2	LubricantsIBA 01/2021 - 12/2019
2	CytokinesIBA 05/2020 - 09/2002
2	Glycoproteins (Glycoprotein)IBA 01/2020 - 09/2004
2	TicagrelorIBA 01/2019 - 07/2014
2	ThromboxanesIBA 01/2019 - 04/2002
2	boldenone undecylenate (Equipoise)IBA 01/2017 - 01/2013
2	Brain Natriuretic Peptide (Natrecor)FDA Link 11/2016 - 09/2016

Therapy/Procedure

69	Therapeutics 07/2022 - 08/2003
7	Knee Replacement Arthroplasty (Total Knee Replacement) 12/2021 - 01/2014
7	Secondary Prevention 12/2019 - 01/2005
7	Catheters 01/2017 - 10/2009
6	Percutaneous Coronary Intervention 01/2019 - 09/2002
5	Duration of Therapy 07/2022 - 09/2016
2	Drug Tapering 01/2022 - 09/2016
2	Drug Therapy (Chemotherapy) 12/2021 - 02/2004